OXYGEN CONSUMPTION, OXYGEN DEBT AND LACTIC ACID IN CIRCULATORY FAILURE 1

Another explanation for decreased oxygen consumption in lactic acidosis

depressed oxygen consumption in patients with lactic acidosis due to biguanide intoxication and they suppose that the cause is inhibited mitochondrial respiration [1]. Another explanation for depressed oxygen consump tion in these patients is also possible, however. If the blood pH is very low, glucose utilization is decreased [2] because the glycolytic enzyme phosphofructokinase is pH dependen...

THE POSSIBLE MECHANISMS OF CONTRACTING AND PAYING THE OXYGEN DEBT AND THE ROLE OF LACTIC ACID IN MUSCULAR CONTRACTION l

Although direct evidence of a quantitative relationship between oxygen debt and lactic acid production in man has never been given, there is general agreement with A. V. Hill’s hypothesis that the oxygen debt is due to the delayed oxidation of a fraction of the lactic acid produced during the anaerobi .c processes of muscular activity. After the “revolution” produced in muscle physiology by the...

Effects of cardiovascular drugs on oxygen consumption/oxygen delivery relationship in patients with congestive heart failure.

The oxygen consumption (VO2)/oxygen delivery (DO2) relationship was analyzed in ten patients with severe congestive heart failure (CHF) and normal blood lactate levels. First dobutamine and then enoximone, after a washout period, were administered to each patient to increase cardiac output by at least 15 percent. Similar increases in DO2 were obtained with both drugs: from 285 +/- 46 to 393 +/-...

Oxygen Consumption in Cycling:

Lean tissue adjusted peak oxygen consumption in congestive heart failure.

We disagree with the comments made by Dr. F. James Brennan that major events were underreported in our recent Journal article (1). Although we used a composite end point that included death, myocardial infarction, cerebrovascular accident and myocardial revascularization, we also separately reported mortality, myocardial infarction, repeat revascularization procedures and stroke (1). For exampl...